The answer appears in a study published in the current issue of the Proceedings of the National Academy of Sciences, USA, Drs. Haining Yang and Michele Carbone at the University of Hawaii Cancer Research Center led a research team that included colleagues at the University of New York, the University of Chicago, University of Pittsburgh, San Raffaele University of Milan, and the Imperial College in London.

These researchers focused on the paradox of how the asbestos fibers that kill cancer cells can cause as a dead cell should not be able to grow and form a tumor. They found that when asbestos kills cells, it does so by inducing a process called programmed cell necrosis, which leads to the release of a molecule called high mobility group box 1 protein (HMGB1). The HMGB1 initiates a particular type of inflammatory reaction that causes the release of mutagens and the factors that promote tumor growth. The researchers found that patients exposed to asbestos have elevated levels of HMGB1 in serum. So, say it is possible to target the HMGB1 to prevent or treat mesothelioma and determine the cohorts exposed to asbestos by simple serological test for HMGB1.
In the article, the researchers propose that by interfering with the inflammatory reaction caused by asbestos and HMGB1 may be possible to reduce the incidence of cancer among generations exposed to asbestos and decrease the rate of tumor growth among those already affected by mesothelioma. Drs. Yang and Carbone, the lead authors, state that to test this hypothesis, they are now planning a clinical trial in a remote area in Cappadocia, Turkey, where over 50% of the population dies of malignant mesothelioma. If results are positive, the approach will be extended to the cohorts of people exposed to asbestos in the U.S..

This research highlights the role of inflammation in the cause of the different types of cancer and provide new clinical tools to identify exposed individuals and prevent or reduce tumor growth. Researchers wonder whether we can prevent this cancer, like colon cancer, by a simple aspirin or similar drugs that stop inflammation. They’re about to test this hypothesis.

The first definitive relationship between mesothelioma and asbestos was made in the 1960s. At that time, asbestos was widely used in the manufacture of insulating materials such as insulation boards and building materials, including cement.

When asbestos is damaged or disturbed, it releases small fibers, almost invisible to the naked eye, which, when air can take a deep breath, and can not be breathed or coughed out. After the fibers are in the lungs, the body’s defense mechanisms try to break them down and remove them, which causes inflammation in lung tissue.

Asbestos fibers can penetrate the lung tissue to settle in the pleura (the lining around the lungs). For years, they can cause asbestosis, mesothelioma or other lung disease to develop. Asbestos fibers also can be swallowed, and some of the fibers to be filed in the digestive system. They will then move to the membrane lining the abdomen (peritoneum), where they cause inflammation.

They most likely have been exposed to asbestos will include: individual construction workers, boilermakers, construction workers, demolition workers, electrical, plumbers, shipbuilders and other family members of those who worked with asbestos and unknowingly brought home asbestos dust on their clothes , will also be at risk and also has been known for mesothelioma developed.

There are three types of asbestos and are: blue, brown and white. Type of brown and blue asbestos are most commonly associated with mesothelioma, and now very rarely used. However, although initially, the white asbestos is not considered dangerous, recent studies have shown that it is also dangerous.

Although in 1999 the import and use of all banned asbestos, and because mesothelioma develops so slowly, it is estimated that in 2015, about 3000 people would have was diagnosed with mesothelioma every year. After this time, the number of people who develop mesothelioma will begin to fall every year.

Mesothelioma does not usually develop for years after the initial exposure to asbestos. While it can take something 10-60 years, averaging around 30 to 40 years after exposure to asbestos.

Occasionally, mesothelioma will be diagnosed in people who have never had a history of asbestos exposure. Other causes of this disease is to date not fully understood, but in rare cases mesothelioma has been linked with radiation exposure.

Research has found evidence that smoking increases the risk of someone developing mesothelioma. It is understood that exposure to other building materials, for example fiberglass will also not increase the risk. Mesothelioma is not a contagious disease and therefore can not be passed on to others. Family members at risk only when in contact with asbestos particles.

Various job sites, ranging from shipyards to chemical and power plants to oil refineries, bear a history of asbestos exposure. If you think you’ve been exposed to asbestos and developed mesothelioma, you should seek mesothelioma law firms for more information on how you can receive compensation.

Public awareness about the benefits and dangers of diseases related to asbestos exposure to asbestos should be better documented. There should be a re-emphasis on the necessity of reducing health hazards to both men and women who may be occupationally exposed to asbestos.

Diseases caused by asbestos does not appear to fifteen to forty years after the first exposure to you. It’s called latency periods “.” Even if you feel healthy while you are working with asbestos, you can get several years after the illness. Exposure to asbestos-related diseases remain a major source of disease. However, millions of Americans who had just exposed to asbestos will continue to suffer the effects.

An asbestos fiber is 400 to 2 000 times smaller than a human hair, allowing it to penetrate to the alveoli: gas exchange take place between air and blood circulation.

Trapped, these fibers can cause inflammation or non-cancerous chromosomal abnormalities, the starting point for benign disease or cancer:

Asbestosis

Asbestos pleural disease asbestosis cancer mésothéliomesLes asbestos fibers enter the lungs and cause inflammation, which is transformed into fibrosis (thickening of lung tissue). It generally takes about ten years between inhalation and onset of the disease. Shortness of breath, dry cough, tightness are the first symptoms can progress to respiratory failure, which can be fatal.

The diagnosis is based on radiography, tomography and functional exploration and detection of asbestos bodies in bronchial secretions.

There is no effective treatment for this disease in decline since the decrease rates of asbestos exposure.

Benign pleural

These lesions of the pleura are not the beginnings of cancer of the lung or pleura (mesothelioma). There are different types of benign pleural pleurisy benign (collection of fluid), pleural fibrosis (sclerosis secondary to pleurisy can sometimes lead to calcification), atelectasis, wound (benign mass developing in the contact of the pleura).

These injuries can sometimes cause a decrease in breathing capacity or pain.

Mesothelioma

Mesothelioma reaches the membrane of the pleura or, less commonly the peritoneum (the protective membrane of the intestines in the abdominal cavity) or the pericardium (membrane that surrounds the heart). The pleural cancer is almost exclusively related to exposure to asbestos. Tobacco is no way implicated in mesothelioma. This disease can develop thirty to forty years after exposure to asbestos.

Mesothelioma is a cancer to occupational exposure to asbestos or asbestos which is the scientific name, asbestos was used for insulation in construction work,in manufacturing industries and thermal cooling in the shipyards for the insulation of vessels in the manufacture of materials such as cement, cement, friction materials, disc brakes and drum brakes, clutch linings Car, as protection against heat and burns, gloves, aprons in foundries, in steel, in flooring, in textiles, etc. … It should be noted that the spraying with asbestos is banned in France since 1977.

Note that since the Decree 96-1133, 24/12/1996, the déflocage buildings, houses, etc. … is mandatory. Asbestos is translated into fine particles that float in the air can be inhaled or swallowed. Professionals and companies now conduct places or asbestos is present.

Mesothelioma is a cancer that affects the lungs, including the pleura, the abdominal cavity including the peritoneal cavity, which often produces metastases to lymph nodes and viscera. the heart with the pericardium, mesothelioma attack is the envelope of these organs.

Asbestos must know is a mineral fiber. Mesothelioma is three times more common among men than among women, by the profession that was exercised. Mesothelioma is recognized as an occupational disease, supported by the Primary Social Security Cases where the relationship with asbestos is medically characterized. The control too recent exhibition will not avert the next decade the increase in the number of cases worldwide. What are the signs of cancer from asbestos?

First, shortness of breath dyspnea and chest pain indicate disease, pleural effusion, pulmonary fibrosis, clubbing, nails become bomber, pleurisy. This cancer is confirmed by the analysis in the sputum of asbestos particles, by chest radiography and biopsy. The first signs appear at about 30-40 years after asbestos exposure. Early signs, mesothelioma, can benefit from surgery that removes most of the tumor. When this stage is exceeded, radiation therapy, can limit the spread of the disease. Chemotherapy has only modest efficacy and has a palliative effect.

Pemetrexed in combination with cisplatin is the standard treatment of cancer from asbestos. Pleural Mesothelioma is a malignant tumor, an extremely aggressive, with asbestos is the major etiological factor to date, it is a certainty. Currently in France and abroad, numerous trials are pending, the state of asbestos litigation and mesothelioma lawsuits occur against these companies, having employed the workers and staff at the time unaware of the dangers and risks of asbestos. Individuals and organizations fighting for fair compensation for those infected. Mesothelioma or asbestos cancer, seems you will become the disease of this century with other cancers and AIDS.

The first is the rise of the early 1900s after the Second World War, because of its exceptional qualities. One found its main use in the shipyards and textile industry.

The second is that its height corresponds to the “Thirty Glorious Years“, that is to say, the industrial development of the 1950, 1960 and 1970. The spread of asbestos was carried out by disregarding all its consequences on human health and relegating to the background of concerns, however legitimate public health.

The third begins in the early 1980s, it is the controlled use, small, that is to say, more thoughtful. However one looks face to face with the issues of human health can become formidable.

The fourth period, which begins with the decision to ban asbestos from 1 January 1997, could, nevertheless, that of renewed confidence in a stated policy of risk management.
I BAN ASBESTOS FOR THE FUTURE: JUSTIFIED FOR ACTION

The decision to ban asbestos, announced July 3, 1996, following the publication of the report of the collective expertise of INSERM, and effective since 1 January 1997, was required. Is a leading public health issues involving the entire population that is the subject of a political decision as absolute, even radical, which terminates the gaps and silences of the past and commits future in a way so clear.

In the past, this procedure was applied in some cases (eg, prohibition of aromatic amines in dyestuffs), but these files did not record the size of the asbestos. Indeed, some uncertainties remain about this case. It was therefore necessary to implement the precautionary principle. This is not the time of the policy of “wait and see” or the maxim “when in doubt, abstain. Today, the policy must take tough political decisions on scientific certainties soft. It’s payback time “when in doubt, decide”.

This decision is a new and fairer approach to scientific, medical and social, that it is more “politically correct” to wait or have proven absolutely safe and knowledge overabundant. It opens when the time came to anticipate risks to prevent people being exposed to. Certainly, there is no reason to ban all substances carcinogenic potential. Indeed, once the cancer risk for a product is identified, there is no prohibition makes sense only if we control this risk, if we do not put the carcinogen in all hands, or if its distribution is done under strict conditions that allow the safe use of the product. In the case of asbestos, a product which has been distributed across an insidious way, we can only make two observations: an inability to control its use and distribution and, although it is difficult for the eliminate, the search for alternative products to replace him.

After reviewing the scientific arguments in favor of this decision showed the failure of the controlled use of asbestos in our country, should be analyzed in more detail and how the policy decision to ban itself.

Mesothelioma is a cancer of pleura (the lining of the lungs), around the inner wall of the heart or the lining of the abdominal cavity. Although cancer mesothelioma is rare, most people die after one or two years of diagnosis.

The majority of mesothelioma cases are traced back to exposure to asbestos – and no other cause of this cancer has never been found. Exposure to asbestos is happening primarily through jobs that were occupied by people working with asbestos, and military service. Until 20 years ago, many products and materials that were used in the manufacture and construction used asbestos until it is found that exposure to the product caused mesothelioma and other problems health.

During the Second World War, when naval shipyards have been producing many ships for the war effort, asbestos was widely used and demand. Asbestos was also used for the construction of all types of buildings, as well as manufacturing and automotive. Until recently, processes and products have been used asbestos unregulated, but the risks of asbestos exposure were well known yet, but companies that use the product continued to use asbestos-free in their practices.

The one truth is unfortunate is that many companies have made use of asbestos has provided little in the way of education or the protection of exposure to asbestos workers. This does however leave companies on the hook for compensation for victims of mesothelioma.

Unfortunately, this is not only the workers who contract mesothelioma, it is also their families, spouses and children of workers who worked with asbestos are also at risk of contact with this deadly cancer. Asbestos is a virtually indestructible, very fine fibers that can be easily inhaled and is then deposited in the lining of the lungs especially, which causes inflammation and mesothelioma. These fibers are easily attached to the back skin, hair, shoes or clothing, then dislodged at home, exposing more people to asbestos, and thusly, mesothelioma.

If someone you love or you have mesothelioma, you need to contact a mesothelioma lawyer to see if you have a case for a lawsuit mesothelioma. The greatest difficulty with exposure to asbestos and mesothelioma symptoms early is the long delay between exposure and diagnosis. Mesothelioma does not usually begin to show symptoms until about 20 years after exposure to asbestos. This makes it very difficult to diagnose cancer and monitoring of exposure to asbestos, the cause or companies that are responsible.

Symptoms of mesothelioma include fluid in the chest, chest pain, difficulty breathing, and coughing. Due to the nature of these symptoms and the fact they are so similar to other medical problems, they are easily confused with other conditions, which may delay diagnosis of mesothelioma cancer. Unfortunately, when people are diagnosed with mesothelioma, it is too late – most people spend one or two years after diagnosis and conventional cancer treatments like radiation and chemotherapy have little effect on disease.

Most cases of mesothelioma can blame the companies and supervisors for whom they have worked in the past with asbestos. Most people and businesses knew of the dangers of working with asbestos and failed to take all precautions for the handling of materials. This cancer is devastating for those who have and their families, physically, emotionally and financially.

A Texas mesothelioma lawyer can help you build a case for you or a loved one has mesothelioma. A Texas mesothelioma attorney is the only one who is able to track companies that are responsible for exposure to asbestos. A good mesothelioma lawyer in Texas can help you to a mesothelioma trial financial compensation for you and your family.

A mesothelioma lawyer can link your cancer with exposure to asbestos that you had when you worked before, and fight for your rights and compensation for the mesothelioma cancer that you have incurred as a result of exposure. While compensation will not replace a life lost to cancer mesothelioma, it can help cover lost wages, pain and suffering, funeral expenses and medical costs that were caused by cancer.

It is possible to observe the occurrence of lesions in groups exposed to low concentrations of asbestos fibers into the air inhaled (environmental exposures in locations containing asbestos exposure and urban).

Two types of studies have been proposed to try to answer the questions on environmental risk, one based on the epidemiology of mesothelioma in women, the other on comparisons between exposed and unexposed.

Occupations involving exposure to asbestos risk being primarily male, it was tempting to analyze the development of mesothelioma in women by attributing these tumors to environmental contamination.

The weight of professional mesothelioma is such that despite the low exposure of women to the risk it introduces a confounding factor that does not allow a comprehensive interpretation of the incidence of mesothelioma in women.

On this point, the report’s conclusion is that the Inserm:
“The analysis of the evolution of the incidence of mesothelioma among women in industrialized countries does not in any way to identify a possible environmental component passive intramural and urban.

It appears, as for men, the professional component and para-professional is such a burden that any additional cases attributable to passive exposure intramural and urban areas is completely indistinguishable in the development of mesothelioma. This does not mean that such an addition does not exist “.

The second method is to compare groups of people exposed and not exposed to risks of environmental contamination, such as working in premises containing asbestos for insulation or protection against fire.

The very limited number of studies using a methodology acceptable (presence of a control group, removal with a thorough study of contamination of the professional type linked to direct intervention on asbestos) does not permit the use of data available in the literature to confirm the absence of risk or its existence.

The report from Inserm analyzes this data and concludes that:
“We must consider it does at present any direct solid epidemiological evidence to make judgments about the health effects associated with environmental exposures passive intramural and locations.

A special situation has been used to try to assess a form of environmental risk, that of people living near an industrial exploitation of asbestos (careers or industries using asbestos, for example, for the production of fibro -cements).

The study appears to be the best documented is that of the female population of the two main mining towns of Canada where asbestos is mined: Asbestos and Thetford.

The reconstruction on the level of risk to which populations of these towns have been exposed (mean concentration and duration) indicates higher values for Thetford for Asbestos, mainly due to the development of measures of environmental protection on the latter Site that divided by a factor greater than 10 the rate of fiber from the beginning of the decade fifty.

The selected values are 40 000 f / lx years for Asbestos and 87 000 Thetford, which should be added exhibitions paraprofessional and servants who combine with environmental exposure.

The available evidence (that a study is not fully completed) indicate no increased risk for cancers of the lung (but women in these regions would be slightly less smoky than the rest of Quebec) and over-risk for mesothelioma.

The six mesotheliomas have been observed in Thetford where the rock used contains tremolite, no cases have been observed in Asbestos, where chrysotile is not contaminated with amphiboles.

According to the Centers for Disease Control and Prevention (CDC), malignant mesothelioma death in the United States from 1999 to 2005 was 18,068 people. The death has increased from 2,482 deaths in 1999 to 2704 in 2005, an increase of 222 deaths.

The men are diagnosed with mesothelioma more often than women and men is 80.8 per cent of mesothelioma deaths during this period (a total of 14,591). The whites are 95.1 percent of deaths from mesothelioma, a total of 17,180.

Effect of age on mortality, aged 75 and over, the majority of patients died of mesothelioma (8858 total deaths). Deaths in patients aged 44 years or less was 311, or 1.7 percent.

During the period covered by the study of the CDC, the state was the death rate from mesothelioma more than the national rate of 13.8 deaths per million people per year. In six countries, the mesothelioma mortality rate was over 20 per million population per year.

The death rate from mesothelioma is highest in Maine, at 27.5 percent (173 total), followed by Wyoming (22.2 per cent, 50 dead), West Virginia (21 percent of 182 deaths ), Pennsylvania (20.8 percent, death 1210), New Jersey (20.2 percent, 814 deaths) and Washington (20.1 percent, 558 deaths).